| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
Alternative mitochondrial functions in cell physiopathology: beyond ATP production
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| Autores: |
Kowaltowski,A.J.
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| Data: |
2000-02-01
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| Ano: |
2000
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| Palavras-chave: |
Mitochondrial permeability transition
Uncoupling proteins
Alternative oxidase
Cardioprotection
Free radicals
Aging
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| Resumo: |
It is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200014
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X2000000200014
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.33 n.2 2000
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| Direitos: |
info:eu-repo/semantics/openAccess
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